ADRB1 Antikörper (Middle Region)

Produktnummer ABIN2774823

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ADRB1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Hund, Kaninchen, Schwein und Meerschweinchen. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für ADRB1 Antikörper (Middle Region) (ABIN2774823)

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Reaktivität: Human, Ratte, Maus, Hund, Kaninchen, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ADRB1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: ADRB1 antibody - middle region

Sequenz: CTVWAISALV SFLPILMHWW RAESDEARRC YNDPKCCDFV TNRAYAIASS

Homologie: Dog: 87%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ADRB1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ADRB1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36551-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ADRB1 Antikörper (ABIN2774823)

Wei, Shen, Song, Qiu, Luo: "Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib." in: Oncology reports, Vol. 36, Issue 3, pp. 1576-84, (2016) (PubMed).

Tsai, Lee, Chen, Kao, Lu, Lin, Chen, Chen: "Testosterone replacement increases aged pulmonary vein and left atrium arrhythmogenesis with enhanced adrenergic activity." in: International journal of cardiology, Vol. 176, Issue 1, pp. 110-8, (2014) (PubMed).

Details zu ADRB1

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Andere Bezeichnung: ADRB1

Hintergrund:

Background Information: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in ADRB1 gene have been shown to affect the resting heart rate and can be involved in heart failure.The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Adrenergic, beta-1-, receptor

Alternative Symbols: RHR, B1AR, FNSS2, ADRB1R, BETA1AR

Protein Name: Beta-1 adrenergic receptor

Molekulargewicht: 51 kDa

Gen-ID: 153

NCBI Accession: NP_000675

UniProt: P08588

Pathways: cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Brown Fat Cell Differentiation