Leptin Receptor Antikörper (Biotin)

Produktnummer ABIN668260

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Leptin Receptor in IHC (p). Es zeigt Reaktivität gegenüber Proben von Schaf.

Kurzübersicht für Leptin Receptor Antikörper (Biotin) (ABIN668260)

Target: Leptin Receptor (LEPR)

Reaktivität: Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Leptin Receptor Antikörper ist konjugiert mit Biotin

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Leptin Receptor Antikörper (Biotin)

Kreuzreaktivität: Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from sheep Leptin R

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Leptin Receptor

Target: Leptin Receptor (LEPR)

Andere Bezeichnung: Leptin receptor/Ob-R

Hintergrund:

Synonyms: obl, CD 295, CD295, CD295 antigen, Db, Fa, HuB219, LEP R, LEPR, LEPROT, Leptin receptor fatty, Leptin receptor gene related protein, Leptin receptor precursor, OB R, OB R gene related protein, OB receptor, OB-RGRP, Obr.

Background: Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain.

Molekulargewicht: 13kDa

Pathways: JAK-STAT Signalweg, AMPK Signaling, Feeding Behaviour