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NMDAR2A Antikörper (N-Term)

GRIN2A Reaktivität: Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6658269
  • Target Alle NMDAR2A (GRIN2A) Antikörper anzeigen
    NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))
    Bindungsspezifität
    • 44
    • 27
    • 25
    • 15
    • 13
    • 12
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 141
    • 114
    • 97
    • 10
    • 10
    • 8
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Ratte
    Wirt
    • 149
    • 51
    • 1
    Kaninchen
    Klonalität
    • 140
    • 61
    Polyklonal
    Konjugat
    • 68
    • 14
    • 14
    • 12
    • 10
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser NMDAR2A Antikörper ist unkonjugiert
    Applikation
    • 160
    • 98
    • 46
    • 31
    • 28
    • 26
    • 26
    • 22
    • 16
    • 15
    • 13
    • 9
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Aufreinigung
    Anti-NMDA R2A antibody is directed against NMDA R2A protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Expect reactivity with the following species based on 100% sequence homology: bovine, canine and mouse.
    Immunogen

    Immunogen: Anti-NMDA R2A Antibody was produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues from the N-terminal region of the NR2A subunit.

    Immunogen Type: Peptide

    Isotyp
    IgG
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  • Applikationshinweise

    Immunohistochemistry Dilution: 1:500

    Application Note: Anti-NMDA R2A Antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 180 kDa in size corresponding to the NR2A subunit of the NMDA receptor in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:1000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
  • Niu, Dai, Liu, Zhang, Yang, Guo, Li, Xu, Huang, Wang, Shi, Liu: "Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory." in: eLife, Vol. 6, (2018) (PubMed).

    Wang, Sanchez-Mendoza, Doeppner, Hermann: "Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 37, Issue 3, pp. 980-993, (2017) (PubMed).

  • Target
    NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))
    Andere Bezeichnung
    NMDA R2A (GRIN2A Produkte)
    Synonyme
    NMDAR2A antikoerper, nr2a antikoerper, GRIN2A antikoerper, EPND antikoerper, GluN2A antikoerper, NR2A antikoerper, glutamate ionotropic receptor NMDA type subunit 2A antikoerper, glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog antikoerper, glutamate receptor ionotropic, NMDA 2A antikoerper, glutamate receptor, ionotropic, NMDA2A (epsilon 1) antikoerper, GRIN2A antikoerper, grin2a.L antikoerper, LOC100438553 antikoerper, Grin2a antikoerper
    Hintergrund

    Synonyms: Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, Grin2a

    Background: NMDA R2A Antibody detects NMDA R2A protein. The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Anti-NMDA R2A Antibody is ideal for investigators involved in Neuroscience, Cell Signaling, and Signal Transduction research.

    Gene Name: GRIN2A

    Gen-ID
    24409
    UniProt
    Q00959
    Pathways
    Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
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