GABRG2 Antikörper (pSer327)
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- Target Alle GABRG2 Antikörper anzeigen
- GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))
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Bindungsspezifität
- pSer327
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GABRG2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Kreuzreaktivität
- Maus, Ratte (Rattus)
- Kreuzreaktivität (Details)
- Cross reactivity with GABA(A) Receptor gamma 2 pS327 from other sources has not been determined
- Aufreinigung
- Anti-GABA(A) Receptor gamma 2 pS327 Antibody is directed against rat phosphorylated GABA(A) Receptor gamma 2. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the GABAA band is completely blocked by lambda-phosphatase treatment. This antibody is directed against rat GABA(A) receptor gamma 2 proteins phosphorylated at Ser327. . However, reactivity is also expected against bovine, canine, chicken, human, and non-human primate.
- Immunogen
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Immunogen: Anti-GABA(A) Receptor gamma 2 pS327 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327.
Immunogen Type: Peptide
- Isotyp
- IgG
- Top Product
- Discover our top product GABRG2 Primärantikörper
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- Applikationshinweise
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Application Note: Anti-GABA(A) Receptor gamma 2 pS327 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 45 kDa in size corresponding to GABA(A) receptor gamma 2 subunit phosphorylated at Ser327 in the appropriate cell lysate or extract.
Western Blot Dilution: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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- Target
- GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))
- Andere Bezeichnung
- GABA(A) Receptor gamma 2 (GABRG2 Produkte)
- Synonyme
- cae2 antikoerper, eca2 antikoerper, gabrg1 antikoerper, gefsp3 antikoerper, si:ch211-145n14.1 antikoerper, CAE2 antikoerper, ECA2 antikoerper, GEFSP3 antikoerper, GABAA-R antikoerper, Gabrg-2 antikoerper, gamma2 antikoerper, gamma-aminobutyric acid type A receptor gamma2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, gamma 2 antikoerper, gamma-aminobutyric acid type A receptor gamma 2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 antikoerper, GABRG2 antikoerper, gabrg2 antikoerper, Gabrg2 antikoerper
- Hintergrund
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Synonyms: Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2
Background: Anti-GABA(A) Receptor gamma 2 pS327 Antibody detects phosphorylated GABA(A) Receptor gamma 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. It has recently been suggested that PKC? regulates the sensitivity of GABAA alpha1-beta2-gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2. GABA(A) Receptor gamma2 pS327 antibody is ideal for investigators involved in Neuroscience.
Gene Name: GABRG2
- Gen-ID
- 29709, 8393403
- UniProt
- P18508
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