SYN1 Antikörper (pSer603)

Produktnummer ABIN6658200

Hersteller Produkt- Nr.: 612-401-c95

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SYN1 in WB. Er zeigt eine Reaktivität gegenüber Ratte und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für SYN1 Antikörper (pSer603) (ABIN6658200)

Target: SYN1 (Synapsin I (SYN1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SYN1 Antikörper

Bindungsspezifität: pSer603

Hersteller Produkt- Nr.: 612-401-c95

Hersteller: Rockland

Verwendungszweck: Synapsin I phospho S603 Antibody

Kreuzreaktivität (Details): The antibody detects Synapsin I that is phosphorylated at S603.

Aufreinigung: Anti-Synapsin I pS603 antibody is directed against bovine Synapsin I.

Immunogen: Anti-Synapsin I pS603 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser603 of Synapsin I.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 1:1000

Kommentare:

Anti-Synapsin I pS603 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 78 kDa in size corresponding to synapsin I doublet protein phosphorylated at Ser603.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Referenzen für anti-SYN1 Antikörper (ABIN6658200)

Engholm-Keller, Waardenberg, Müller, Wark, Fernando, Arthur, Robinson, Dietrich, Schoch, Graham: "The temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation." in: PLoS biology, Vol. 17, Issue 3, pp. e3000170, (2019) (PubMed).

Hammond, Lu, Gelbard: "Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation." in: Frontiers in cellular neuroscience, Vol. 9, pp. 505, (2016) (PubMed).

Details zu SYN1

Target: SYN1 (Synapsin I (SYN1))

Andere Bezeichnung: Synapsin I

Hintergrund:

Synonyms: Synapsin I, SYN1

Background: Synapsin I pS603 antibody is directed against rat Synapsin I, whcih plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Serine 603 is the site on synapsin I that is phosphorylated by calcium calmodulin kinase II and by p21-activated kinases. Phosphorylation of this site is thought to regulate synaptic vesicle function. Anti-Synapsin I pS603 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: SYN1

Gen-ID: 24949

NCBI Accession: NP_001104252

UniProt: P09951