KCNK3 Antikörper (AA 251-411)

Produktnummer ABIN6658182

Hersteller Produkt- Nr.: 200-301-w85

Dieses Maus Monoklonal-Antikörper erkennt spezifisch KCNK3 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für KCNK3 Antikörper (AA 251-411) (ABIN6658182)

Target: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KCNK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Klon: S374-48

Produktdetails anti-KCNK3 Antikörper

Bindungsspezifität: AA 251-411

Hersteller Produkt- Nr.: 200-301-w85

Hersteller: Rockland

Verwendungszweck: TASK1 Potassium Channel Antibody

Kreuzreaktivität (Details): BLAST analysis suggests that it is 96 % identical to mouse, 76 % identical to human, and <30 % identical to TASK3.

Aufreinigung: Anti-TASK1 Potassium Channel Antibody was purified from concentrated tissue culture supernate by Protein G chromatography.

Sterilität: Sterile filtered

Immunogen: Anti-TASK1 Potassium Channel Antibody was produced by repeated immunization of mice with a fusion protein containing amino acids 251-411 of rat TASK1.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Kommentare:

Anti-TASK1 Potassium Channel Antibody is suitable for Western Blots, Immunohistochemistry and Immunocytochemistry. Expect a band approximately ~50kDa on specific lysates or tissues. Does not cross react with TASK3. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: 0.1 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu KCNK3

Target: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Andere Bezeichnung: Kcnk3

Hintergrund:

Synonyms: Potassium channel subfamily K member 3, KCNK3, Acid sensitive potassium channel protein TASK 1, Cardiac two pore background K(+) channel, cTBAK 1, K2p3.1, KCNK9, OAT1, potassium channel subfamily K member 3, rTASK, TASK 1, TBAK1

Background: K+ channels are divided into three subclasses reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions and include TWIK, TREK, TRAAK and TASK. TASK channels are highly sensitive to external pH in the physiological range. TASK-1 is expressed in brain and in rat heart, with high levels of expression in the right atrium. TASK-2, mainly expressed in kidney, is localized in cortical distal tubules and collecting ducts, suggesting a role in renal K+ transport. TASK-3 from rat cerebellum shares 54 % identity with TASK-1, but less than 30 % identity with TASK-2 and other tandem pore K+ channels. Anti-TASK1 Potassium Channel Antibody is ideal for research in Neuroscience, particularly studies concerning the dopaminergic neuron and melatonin signaling.

Gene Name: TASK1

Gen-ID: 29553

NCBI Accession: NP_203694

UniProt: O54912