NMDAR2A Antikörper (C-Term)

Produktnummer ABIN6658061

Hersteller Produkt- Nr.: 600-401-c86

Dieses Anti-NMDAR2A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NMDAR2A in WB, IHC und IP. Geeignet für Ratte.

Kurzübersicht für NMDAR2A Antikörper (C-Term) (ABIN6658061)

Target: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMDAR2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-NMDAR2A Antikörper

Bindungsspezifität: C-Term

Hersteller Produkt- Nr.: 600-401-c86

Hersteller: Rockland

Verwendungszweck: NMDA NR2A Subunit Antibody

Kreuzreaktivität (Details): Anti-NMDA NR2A Subunit antibody is directed against NMDA NR2A protein.

Aufreinigung: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-NMDA NR2A subunit Antibody was produced by repeated immunizations with a fusion protein from the C-terminal region of the NR2A subunit.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunoprecipitation_Dilution: 3 μL per 200 μg lysate

Immunohistochemistry_Dilution: 1:1000-1:2000

Western_Blot_Dilution: 1:1000

Other: User Optimized

Kommentare:

Anti-NMDA NR2A Subunit (Rabbit) Antibody is tested for use in Western Blotting, Immunoprecipitation and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 180 kDa in size corresponding to the NR2A subunit of the NMDA receptor. This antibody is lyophilized from 5 mM ammonium bicarbonate.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution:

Reconstitution_Buffer: Neutral PBS

Reconstitution_Volume: 50μL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu NMDAR2A

Target: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Andere Bezeichnung: NMDA NR2A Subunit

Hintergrund:

Synonyms: Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, Grin2a

Background: NMDA NR2A Subunit antibody detects NMDA NR2A protein. The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Anti-NMDA NR2A Subunit Antibody is ideal for investigators involved in Neuroscience and Signal Transduction research.

Gene Name: GRIN2A

Gen-ID: 24409

NCBI Accession: NP_036705

UniProt: Q00959

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity