BIRC7 Antikörper

Produktnummer ABIN6655300

Hersteller Produkt- Nr.: 200-301-h90

Der Maus Monoklonal Anti-BIRC7-Antikörper wurde für WB, IF und FM validiert. Er ist geeignet, BIRC7 in Proben von Human zu detektieren.

Kurzübersicht für BIRC7 Antikörper (ABIN6655300)

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BIRC7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Fluorescence Microscopy (FM)

Klon: 88C570

Produktdetails anti-BIRC7 Antikörper

Hersteller Produkt- Nr.: 200-301-h90

Hersteller: Rockland

Verwendungszweck: Livin Antibody

Kreuzreaktivität (Details): A BLAST analysis was used to suggest cross-reactivity with Livin from human based on 100 % homology with the immunizing sequence.

Aufreinigung: Anti-Livin Antibody was purified by Protein G chromatography.

Immunogen: Livin Antibody was produced in mice prepared by repeated immunizations with recombinant human protein, Livin.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

IF_Microscopy_Dilution: 2-5 μg/mL

Western_Blot_Dilution: 1-2 μg/mL

Kommentare:

Anti-Livin antibody is tested for use in IF/ICC and WB. Expect a band approximately 30kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

Preservative: 0.05 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu BIRC7

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Andere Bezeichnung: Livin

Hintergrund:

Synonyms: KIAP, LIVIN, MLIAP, RNF50, BIRC7, Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, Melanoma inhibitor of apoptosis protein, ML-IAP, RING finger protein 50

Background: Anti-Livin BIRC7 KIAP antibody detects human Livin BIRC7 KIAP. The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently a novel human inhibitor of apoptosis protein (IAP) family member termed Livin or ML-IAP, which contains a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain, has been identified. Livin gene has two splicing variants that contain open reading frames of 298 and 280 amino acids and both contained a single copy of baculovirus IAP repeat (BIR) and RING domain. Both of the isoforms inhibit TNFa induced apoptosis in Jurkat cells. Livin expression is low in adult tissues. It is relatively expressed at a higher level in developmental tissues and in many cancer cells. Anti-Livin BIRC7 KIAP antibody is ideal for investigators invovled in apoptosis reasearch.

Gene Name: BIRC7

Gen-ID: 79444

NCBI Accession: NP_071444

UniProt: Q96CA5