IFNAR1 Antikörper (pSer535, pSer539)

Produktnummer ABIN6655258

Hersteller Produkt- Nr.: 600-401-d67

Der Kaninchen Polyklonal Anti-IFNAR1-Antikörper wurde für WB und IHC validiert. Er ist geeignet, IFNAR1 in Proben von Human zu detektieren.

Kurzübersicht für IFNAR1 Antikörper (pSer535, pSer539) (ABIN6655258)

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFNAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-IFNAR1 Antikörper

Bindungsspezifität: pSer535, pSer539

Hersteller Produkt- Nr.: 600-401-d67

Hersteller: Rockland

Verwendungszweck: Interferon alpha Receptor Type I phospho S535/phospho S539 Antibody

Kreuzreaktivität (Details): Anti-Interferon alpha Receptor Type I pS535/pS539 Antibody is directed against human Interferon alpha Receptor Type I phosphorylated at positions S535/S539.

Aufreinigung: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Immunogen: Anti-Interferon alpha Receptor Type I pS535/pS539 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry_Dilution: 1:1000

Western_Blot_Dilution: 1:1000

Other: Dot Blot: 1:1000

Kommentare:

Anti-Interferon alpha Receptor Type I pS535/pS539 (Rabbit) antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. The molecular weight of the IFNAR1 varies with cell line due to different levels of glycosylation in 293 and HeLa Cells, the mature form is approximately 110-130 kDa in size.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu IFNAR1

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Andere Bezeichnung: Interferon alpha Receptor Type I

Hintergrund:

Synonyms: Interferon alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1

Background: Interferon alpha Receptor Type I pS535/pS539 Antibody detects Interferon alpha Receptor Type I phopshorylated at positions S535/S539. Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1. Therefore, Interferon alpha Receptor Type I phospho S535/phospho S539 antibody is ideal for investigators involved in Cell Signaling, Virology, Immunology and Cancer Research.

Gene Name: IFNAR1

Gen-ID: 3454

UniProt: P17181

Pathways: JAK-STAT Signalweg, Hepatitis C