GSTM2 Antikörper (full length)

Produktnummer ABIN6654840

Dieser Maus Monoklonal Antikörper detektiert spezifisch GSTM2 in IF, FACS und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für GSTM2 Antikörper (full length) (ABIN6654840)

Target: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GSTM2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: CPTC-GSTMu2-2

Produktdetails anti-GSTM2 Antikörper

Bindungsspezifität: full length

Verwendungszweck: GSTM2 Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: Full length recombinant human protein was used as the immunogen for this GSTM2 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GSTM2 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the GSTM2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu GSTM2

Target: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Andere Bezeichnung: GSTM2

Hintergrund: Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. There are eight families of GST proteins, each of which are composed of proteins that have a variety of functions throughout the cell. The GSTM proteins (GSTM1-GSTM5 in human and GSTM1-GSTM7 in mouse) are members of the mu class of enzymes that conjugate with glutathione and function in the detoxification of carcinogens, environmental toxins and products of oxidative stress. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. GSTM2 is specific for muscle hence the alternate name GST muscle antibody.

UniProt: P28161

Pathways: Negative Regulation of Transporter Activity