MMP2 Antikörper

Produktnummer ABIN659015

Der Maus Monoklonal Anti-MMP2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, MMP2 in Proben von Human zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für MMP2 Antikörper (ABIN659015)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 6E3F8

Produktdetails anti-MMP2 Antikörper

Aufreinigung: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This MMP2 antibody is generated from mouse immunized with MMP2 recombinant protein.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:200~1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-MMP2 Antikörper (ABIN659015)

Zhou, Wang, Ban, Zeng, Zhu, Li, Guan, Li: "DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma." in: Oncogene, Vol. 37, Issue 8, pp. 1086-1094, (2018) (PubMed).

Li, Zhou, Yang, Zhou, Tan, Yuan, Song, Chen, Zhang: "The CD147/MMP-2 signaling pathway may regulate early stage cardiac remodelling in spontaneously hypertensive rats." in: Clinical and experimental pharmacology & physiology, Vol. 43, Issue 11, pp. 1125-1133, (2017) (PubMed).

Huang, Chiu, Chou, Su, Chen, Chai, Huang, Huang, Yuan, Lee: "Association of MMP-2 and MMP-9 expression with recurrences in primary spontaneous pneumothorax." in: The Kaohsiung journal of medical sciences, Vol. 33, Issue 1, pp. 17-23, (2017) (PubMed).

Wang, Cao, Huang, Ke, Luo, Lin, Wang, Zhang, Wang: "EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-κB signaling pathway." in: Oncotarget, Vol. 6, Issue 16, pp. 14191-208, (2016) (PubMed).

Details zu MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Andere Bezeichnung: MMP2

Hintergrund: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 73882

Gen-ID: 4313

NCBI Accession: NP_001121363, NP_004521

UniProt: P08253

Pathways: Activation of Innate immune Response