E2F4 Antikörper (AA 61-110)

Produktnummer ABIN6579716

Der Kaninchen Polyklonal anti-E2F4 Antikörper wird verwendet zum Nachweis von E2F4 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC und IF.

Kurzübersicht für E2F4 Antikörper (AA 61-110) (ABIN6579716)

Target: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser E2F4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-E2F4 Antikörper

Bindungsspezifität: AA 61-110

Verwendungszweck: E2F-4 Antibody

Spezifität: E2F-4 Polyclonal Antibody detects endogenous levels of E2F-4 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human E2F4 around the non-acetylation site of Lys96. AA range:61-110

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu E2F4

Target: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Andere Bezeichnung: E2F4

Hintergrund:

Synonyms: E2F4, Transcription factor E2F4, E2F-4

Background: The protein encoded byThis gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated ge

Gene Name: E2F4

Protein Name: Transcription factor E2F4

Molekulargewicht: 43 kDa

Gen-ID: 1874

OMIM: 600659

UniProt: Q16254

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size