Neuregulin 3 Antikörper (AA 311-360)

Produktnummer ABIN6579621

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Neuregulin 3 in WB, IHC, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für Neuregulin 3 Antikörper (AA 311-360) (ABIN6579621)

Target: Neuregulin 3 (NRG3)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Neuregulin 3 Antikörper

Bindungsspezifität: AA 311-360

Verwendungszweck: Neuregulin-3 Antibody

Spezifität: Neuregulin-3 Polyclonal Antibody detects endogenous levels of Neuregulin-3 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NRG3. AA range:311-360

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Neuregulin 3

Target: Neuregulin 3 (NRG3)

Andere Bezeichnung: NRG3

Hintergrund:

Synonyms: NRG3, Pro-neuregulin-3, membrane-bound isoform, Pro-NRG3

Background: This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis.This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcri

Gene Name: NRG3

Protein Name: Pro-neuregulin-3 membrane-bound isoform

Molekulargewicht: '77 kDa

Gen-ID: 10718

OMIM: 605533

UniProt: P56975

Pathways: RTK Signalweg