JMJD2D Antikörper (AA 337-359)

Produktnummer ABIN6579170

Der Kaninchen Polyklonal anti-JMJD2D Antikörper wird verwendet zum Nachweis von JMJD2D in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für JMJD2D Antikörper (AA 337-359) (ABIN6579170)

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JMJD2D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-JMJD2D Antikörper

Bindungsspezifität: AA 337-359

Verwendungszweck: JMJD2D antibody (pAb)

Aufreinigung: Affinity Purified

Immunogen: This JMJD2D antibody was raised against a peptide corresponding to amino acids 337-359 of human JMJD2D.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500 - 1:2,000 dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified rabbit IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu JMJD2D

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Andere Bezeichnung: JMJD2D

Hintergrund: JMJD2D (KDM4D) is a histone demethylase located in the nucleus that specifically demethylates Lysine 9 of Histone H3, thereby playing a central role in the histone code. JMJD2D (KDM4D) demethylates both di- and trimethylated histone H3 Lys 9, while it has no activity on monomethylated residues. The demethylation reaction of the Lys residue generates formaldehyde and succinate as a by product. In addition, JMJD2D forms a complex with the ligand-bound form of the Androgen Receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D (KDM4D) may be involved in carcinogenesis.

Molekulargewicht: 58 kDa

Gen-ID: 55693

NCBI Accession: NP_060509

Pathways: Warburg Effekt