TSG101 Antikörper

Produktnummer ABIN190317

Dieses Anti-TSG101-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von TSG101 in WB, IP, IF/ICC, PLA und BP. Geeignet für Human.

Kurzübersicht für TSG101 Antikörper (ABIN190317)

Target: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TSG101 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC), Proximity Ligation Assay (PLA), Blocking Peptide (BP)

Klon: 1F3

Produktdetails anti-TSG101 Antikörper

Verwendungszweck: Anti-DNA Ligase III Mouse Monoclonal Antibody

Spezifität: This antibody recognizes human, mouse, and chicken DNA Ligase III. Cellular localization is nuclear and mitochondrial.

Kreuzreaktivität: Huhn, Human, Maus

Immunogen: Full-length recombinant human DNA Ligase III-b.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunoblotting: use at 0.5-2 μg/mL. Predicted molecular weight ~100 kDa.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Dilute in PBS or medium which is identical to that used in the assay system.

Konzentration: 1.0 mg/mL

Buffer: Hybridoma culture supernatant

Lagerung: -20 °C

Informationen zur Lagerung: This antibody is stable for at least one year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.

Details zu TSG101

Target: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Andere Bezeichnung: TSG101

Hintergrund: DNA ligase 3,Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {PubMed:10207110, PubMed:24674627}.,There are four distinct ligase proteins found in mammalian cells. These DNA ligases are required for joining DNA strand breaks that occur during DNA replication, repair and recombination. DNA Ligase III is a 100 kDa (a-form) protein in somatic tissues, is ubiquitously expressed, and complexes with XRCC-1 and a 97 kDa ( -form) protein that is found in testis. DNA Ligase III is involved in rejoining DNA single-strand breaks and in base excision repair pathway.,[Isoform 1]: Mitochondrion,EC 6.5.1.1, DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3

UniProt: P49916