B-Cell Linker Antikörper (N-Term)

Produktnummer ABIN657356

Der Kaninchen Polyklonal Anti-B-Cell Linker-Antikörper wurde für WB validiert. Er ist geeignet, B-Cell Linker in Proben von Human zu detektieren.

Kurzübersicht für B-Cell Linker Antikörper (N-Term) (ABIN657356)

Target: B-Cell Linker (BLNK)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser B-Cell Linker Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB18882

Produktdetails anti-B-Cell Linker Antikörper

Bindungsspezifität: AA 57-82, N-Term

Homologie: M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BLNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-82 amino acids from the N-terminal region of human BLNK.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: BLNK Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Details zu B-Cell Linker

Target: B-Cell Linker (BLNK)

Andere Bezeichnung: BLNK

Hintergrund: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 50466

Gen-ID: 29760

NCBI Accession: NP_001107566, NP_001245369, NP_037446

UniProt: Q8WV28

Pathways: BCR Signaling