NSD1 Antikörper (Nuclear Receptor Binding SET Domain Protein 1)

Details for Product anti-NSD1 Antibody No. ABIN6572111
Antigen
  • NSD1
  • sto
  • kmt3b
  • sotos
  • ara267
  • ARA267
  • KMT3B
  • SOTOS
  • SOTOS1
  • STO
  • AI528500
  • nuclear receptor binding SET domain protein 1
  • histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
  • nuclear receptor-binding SET-domain protein 1
  • NSD1
  • nsd1
  • Nsd1
  • LOC540197
Reaktivität
Human, Maus
47
23
15
2
Wirt
Kaninchen
32
17
Klonalität
Polyklonal
Konjugat
Dieser NSD1 Antikörper ist unkonjugiert
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
20
14
13
8
4
4
2
1
1
Optionen
Immunogen Recombinant protein of human NSD1
Isotyp IgG
Reinigung Affinity purification
Plasmids, Primers & others Plasmide, Primers & weitere NSD1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung NSD1 (NSD1 Antibody Abstract)
Hintergrund

Synonyms: Nuclear Receptor Binding SET Domain Protein 1,Nuclear Receptor-Binding SET Domain-Containing Protein 1,Androgen Receptor-Associated Protein Of 267 KDa,Androgen Receptor Coactivator 267 KDa Protein,NR-Binding SET Domain-Containing Protein,Lysine N-Methyltransferase 3B,H3-K36-HMTase,H4-K20-HMTase,EC 2.1.1.43.

Background: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Molekulargewicht

Observed_MW: 297kDa

Calculated_MW: 267kDa/284kDa/296kDa

Gen-ID 64324
UniProt Q96L73
Applikations-hinweise WB 1:500 - 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder des Herstellers
Image no. 1 for anti-Nuclear Receptor Binding SET Domain Protein 1 (NSD1) antibody (ABIN6572111) Western blot analysis of extracts of various cell lines, using NSD1 antibody.
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