KIR3DS1 Antikörper

Produktnummer ABIN6572080

Produktdetails anti-KIR3DS1 Antikörper

Target: KIR3DS1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Short Cytoplasmic Tail, 1 (KIR3DS1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIR3DS1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human KIR3DS1 (NP_001077008.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu KIR3DS1

Target: KIR3DS1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Short Cytoplasmic Tail, 1 (KIR3DS1))

Andere Bezeichnung: KIR3DS1 (KIR3DS1 Produkte)

Synonyme: CD158E2 antikoerper, KIR-123FM antikoerper, KIR-G1 antikoerper, NKAT10 antikoerper, killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 antikoerper, killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 antikoerper, KIR3DS1 antikoerper

Hintergrund: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht:

Observed_MW: 60kDa

Calculated_MW: 42kDa

Gen-ID: 3813

UniProt: Q14943