Synonyms: A530055J10,alpha-E1,alpha-M290,aM290,Antigen CD103,CD 103,CD103,CD103 antigen,HML 1 antigen,HML-1 antigen,HML1 antigen,Human mucosal lymphocyte antigen 1,Human mucosal lymphocyte antigen 1,alpha subunit,Huminae,Integrin alpha E heavy chain,Integrin alpha E light chain,Integrin alpha E,epithelial-associated,Integrin alpha E1,Integrin alpha IEL,Integrin alpha M290,Integrin alpha-E heavy chain,Integrin alpha-IEL,Integrin,alpha E (antigen CD103,human mucosal lymphocyte antigen 1,alpha polypeptide),Integrin,alpha E,ITAE,Itgae,MGC141996,MGC183601,Mucosal lymphocyte 1 antigen,Mucosal lymphocyte antigen 1
Background: Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.