Far Upstream Element (FUSE) Binding Protein 1 (FUBP1) Antikörper

Details zu Produkt Nr. ABIN6569996
Antigen
Reaktivität
Human, Maus
77
37
32
7
7
6
5
4
3
3
3
2
2
1
Wirt
Kaninchen
60
11
7
Klonalität
Polyklonal
Konjugat
Unkonjugiert
6
4
3
3
3
3
2
2
2
2
2
2
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
65
39
16
10
7
6
5
4
2
2
1
1
Optionen
Immunogen Recombinant protein of human FUBP1
Isotyp IgG
Reinigung Affinity purification
Antigen
Andere Bezeichnung FUBP1 (FUBP1 Antibody Abstract)
Hintergrund

Synonyms: DNA helicase V,far upstream element (FUSE) binding protein 1,Far upstream element (FUSE) binding protein 4,Far upstream element binding protein 1,far upstream element binding protein,Far upstream element-binding protein 1,FBP,FUBP,Fubp1,FUBP1,Fubp4,FUSE binding protein 1,FUSE-binding protein 1,HDH V

Background: The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.

Molekulargewicht

Observed_MW: 79kDa

Calculated_MW: 67kDa/68kDa

Gen-ID 8880
UniProt Q96AE4
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder des Herstellers
Image no. 1 for anti-Far Upstream Element (FUSE) Binding Protein 1 (FUBP1) antibody (ABIN6569996) Immunohistochemistry of paraffin-embedded mouse brain using FUBP1 antibody.
Image no. 2 for anti-Far Upstream Element (FUSE) Binding Protein 1 (FUBP1) antibody (ABIN6569996) Immunohistochemistry of paraffin-embedded human liver injury using FUBP1 antibody.
Image no. 3 for anti-Far Upstream Element (FUSE) Binding Protein 1 (FUBP1) antibody (ABIN6569996) Western blot analysis of extracts of various cell lines, using FUBP1 antibody.