Androgen Receptor Antikörper (Center)

Produktnummer ABIN656982

Dieses Anti-Androgen Receptor-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Androgen Receptor in WB. Geeignet für Human.

Kurzübersicht für Androgen Receptor Antikörper (Center) (ABIN656982)

Target: Androgen Receptor (AR)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Androgen Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB32967

Produktdetails anti-Androgen Receptor Antikörper

Bindungsspezifität: AA 282-309, Center

Spezifität: This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the Central region of human AR.

Homologie: Monkey

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 AA from the Central region of human AR.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB = 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.33 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: AR Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Details zu Androgen Receptor

Target: Androgen Receptor (AR)

Andere Bezeichnung: AR

Hintergrund: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].
Synonyms: Androgen receptor,AR,DHTR, NR3C4

Molekulargewicht: 98989 DA

Gen-ID: 367

NCBI Accession: NP_001011645, NP_000035

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding