Synonyms: FLJ31113,IMA3,Importin alpha 3,Importin alpha 4 subunit,Importin alpha Q1,Importin subunit alpha 3,Importin subunit alpha-3,IPO A3,IPOA 3,IPOA3,Karyopherin alpha 4 (importin alpha 3),Karyopherin alpha 4,Karyopherin alpha 4 importin alpha 3,Karyopherin alpha 4 subunit,Karyopherin subunit alpha 4 ,Karyopherin subunit alpha-4,KPNA 4,Kpna4,MGC12217,MGC26703,OTTHUMP00000213880,QIP 1,Qip1,Qip1 protein,SRP 3,SRP3
Background: The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.