Synonyms: CHI3,CHIT,CHIT1,CHIT1,CHITD,Chitinase 1 ,Chitinase 1 (chitotriosidase),Chitinase-1,Chitotriosidase,Chitotriosidase-1,EC 18.104.22.168,FLJ00314,MGC125322,Plasma methylumbelliferyl tetra N acetylchitotetraoside hydrolase
Background: Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.