Synonyms: hU2AF(65),hU2AF65,Splicing factor U2AF 65 kDa subunit,U2 (RNU2) small nuclear RNA auxiliary factor 2,U2 auxiliary factor 65 kDa subunit,U2 small nuclear ribonucleoprotein auxiliary factor (65kD),U2 small nuclear RNA auxiliary factor 2,U2 snRNP auxiliary factor large subunit,U2af2,U2AF2,U2AF65
Background: U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.