Synonyms: 55 kDa actin bundling protein,55 kDa actin-bundling protein,Actin bundling protein,actin bundling protein,55-KD,FAN 1,FAN1,Fascin 1,Fascin actin bundling protein 1,Fascin,Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus),Fascin homolog 1,Fascin,sea urchin,homolog of,1,Fascin1,FLJ38511,FSCN 1,FSCN1,FSCN1,HSN,p55,Singed (Drosophila) like (sea urchin fascin homolog like),Singed drosophila homolog like,Singed like (fascin homolog sea urchin) (Drosophila),Singed like (fascin homolog sea urchin),Singed like protein,Singed,drosophila,homolog of,Singed-like protein,SNL,Strongylocentrotus purpuratus
Background: This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.