IL12RB1 Antikörper (Interleukin 12 Receptor beta 1)

Details for Product anti-IL12RB1 Antibody No. ABIN6568961
Target
Reaktivität
Human, Maus
51
21
20
Wirt
Kaninchen
55
10
6
Klonalität
Polyklonal
Konjugat
Dieser IL12RB1 Antikörper ist unkonjugiert
8
5
5
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
38
17
13
12
12
5
4
3
3
3
3
1
Optionen
Immunogen Recombinant protein of human IL12RB1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung IL12RB1 (IL12RB1 Antibody Abstract)
Hintergrund

Synonyms: CD212,cluster of differentiation 212,I12R1,IL-12 receptor beta component,IL-12 receptor subunit beta-1,IL-12R subunit beta-1,IL-12R-beta-1,IL-12RB1,IL12 receptor beta component,IL12RB,Il12rb1,IMD3,IMD30,Interleukin 12 receptor beta 1 chain,Interleukin 12 receptor subunit beta 1,Interleukin-12 receptor subunit beta-1,MGC34454

Background: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

Molekulargewicht

Observed_MW: 73kDa

Calculated_MW: 42kDa/72kDa/73kDa

Gen-ID 3594
UniProt P42701
Pathways JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
Applikations-hinweise WB 1:500 - 1:2000 IF 1:10 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Interleukin 12 Receptor beta 1 (IL12RB1) antibody (ABIN6568961) Western blot analysis of extracts of various cell lines, using IL12RB1 antibody.
Image no. 2 for anti-Interleukin 12 Receptor beta 1 (IL12RB1) antibody (ABIN6568961) Immunofluorescence analysis of A549 cells using IL12RB1 antibody.