CD59 Antikörper (CD59)

Details for Product anti-CD59 Antibody No. ABIN6568850
Target
Reaktivität
Human, Maus, Ratte
230
16
16
8
8
3
3
2
2
1
1
Wirt
Kaninchen
160
97
7
6
Klonalität
Polyklonal
Konjugat
Dieser CD59 Antikörper ist unkonjugiert
29
22
16
8
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
2
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
171
91
87
62
51
40
35
34
32
18
18
15
13
11
5
4
3
2
1
1
1
1
Optionen
Immunogen Recombinant protein of human CD59
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung CD59 (CD59 Antibody Abstract)
Hintergrund

Synonyms: 16.3A5,1F5,1F5 antigen,20 kDa homologous restriction factor,CD 59,CD_antigen=CD59,CD59,CD59 antigen,CD59 antigen complement regulatory protein ,CD59 antigen p18 20,CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5,EJ16,EJ30,EL32 and G344),CD59 glycoprotein,CD59 Molecule,CD59 Molecule complement regulatory protein,CD59,Cd59a,Complement regulatory protein,EJ16,EJ30,EL32,FLJ38134,FLJ92039,G344,HRF 20,HRF-20,HRF20,Human leukocyte antigen MIC11,Ly 6 like protein,Lymphocytic antigen CD59/MEM43,MAC inhibitory protein,MAC IP,MAC-inhibitory protein,MAC-IP,MACIF,MACIP,MEM43,MEM43 antigen,Membrane attack complex (MAC) inhibition factor,Membrane attack complex inhibition factor,Membrane inhibitor of reactive lysis,MGC2354,MIC11,MIN1,MIN2,MIN3,MIRL,MSK21,p18 20,Protectin,Surface antigen recognized by monoclonal 16.3A5,T cell activating protein

Background: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Molekulargewicht

Observed_MW: 17kDa

Calculated_MW: 14kDa

Gen-ID 966
UniProt P13987
Pathways Komplementsystem
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-CD59 (CD59) antibody (ABIN6568850) Western blot analysis of extracts of various cell lines, using CD59 antibody.
Image no. 2 for anti-CD59 (CD59) antibody (ABIN6568850) Immunohistochemistry of paraffin-embedded mouse brain using CD59 antibody.
Image no. 3 for anti-CD59 (CD59) antibody (ABIN6568850) Immunohistochemistry of paraffin-embedded mouse lung using CD59 antibody.