CD59 Antikörper

Produktnummer ABIN6568850

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch CD59 in IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für CD59 Antikörper (ABIN6568850)

Target: CD59

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD59 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-CD59 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human CD59

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CD59

Target: CD59

Andere Bezeichnung: CD59

Hintergrund: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Molekulargewicht:

Observed_MW: 17kDa

Calculated_MW: 14kDa

Gen-ID: 966

UniProt: P13987

Pathways: Komplementsystem