Synonyms: 59 kDa bone sialic acid-containing protein,A2HS,Aa2-066,AHS,Ahsg alpha-2-HS-glycoprotein,Ahsg,Alpha 2 HS Glycoprotein,Alpha 2 Z globulin,Alpha-2-HS-glycoprotein,Alpha-2-HS-glycoprotein chain B,Alpha-2-Z-globulin,Asialofetuin,Ba alpha 2 glycoprotein,Ba-alpha-2-glycoprotein,BSP,Countertrypin,Fetua,FETUA,Fetuin,mouse,homolog of,Fetuin A,Fetuin-A,Glycoprotein PP63,HSGA,pp63
Background: Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure.