Synonyms: A1 140 kDa subunit,A1,A1 P145 Activator 1 large subunit,Activator 1 140 kDa subunit,Activator 1 large subunit,Activator 1 subunit 1,DNA binding Protein PO GA,DNA-binding protein PO-GA,MHC binding factor beta,MHCBFB,PO GA,RECC1,Replication factor C (activator 1) 1,145 kDa,Replication factor C 140 kDa subunit,Replication factor C,Replication factor C large subunit,Replication factor C subunit 1,Replication factor C1,RF-C 140 kDa subunit,RFC,RFC1,RFC1,RFC140,RFC140 Replication Factor C 140 kDa subunit
Background: This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.