KPNA2 Antikörper (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1))

Details for Product anti-KPNA2 Antibody No. ABIN6568809
Target
Reaktivität
Human, Maus
62
32
29
2
2
2
1
1
1
1
1
Wirt
Kaninchen
43
9
7
3
1
Klonalität
Polyklonal
Konjugat
Dieser KPNA2 Antikörper ist unkonjugiert
4
2
2
2
2
2
2
2
2
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
48
24
14
12
9
6
5
3
3
2
1
1
1
Optionen
Immunogen Recombinant protein of human KPNA2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung KPNA2 (KPNA2 Antibody Abstract)
Hintergrund

Synonyms: IMA1,Importin alpha 1,Importin alpha 2,Importin alpha 2 subunit,Importin alpha P1,Importin subunit alpha-1,IPO A1,IPOA 1,IPOA1,Karyopherin alpha 2,Karyopherin alpha 2 RAG cohort 1,Karyopherin alpha 2 subunit,Karyopherin subunit alpha-2,KPNA2,KPNA2 protein,Pendulin,QIP 2,QIP2,RAG cohort 1,RAG cohort protein 1,RCH 1,RCH1,SRP 1,SRP1 alpha,SRP1,SRP1-alpha,SRP1alpha

Background: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.

Molekulargewicht

Observed_MW: 60kDa

Calculated_MW: 57kDa

Gen-ID 3838
UniProt P52292
Pathways M Phase, Protein targeting to Nucleus
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) antibody (ABIN6568809) Western blot analysis of extracts of various cell lines, using KPNA2 antibody.
Image no. 2 for anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) antibody (ABIN6568809) Immunofluorescence analysis of MCF-7 cells using KPNA2 antibody.