TAP2 Antikörper (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP))

Details for Product anti-TAP2 Antibody No. ABIN6568799
Target
Reaktivität
Human, Maus, Ratte
45
24
24
Wirt
Kaninchen
45
1
Klonalität
Polyklonal
Konjugat
Dieser TAP2 Antikörper ist unkonjugiert
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
22
17
16
15
13
5
2
1
1
1
1
Optionen
Immunogen Recombinant protein of human TAP2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung TAP2 (TAP2 Antibody Abstract)
Hintergrund

Synonyms: ABC transporter,MHC 2,ABC18,ABCB3,Antigen peptide transporter 2,APT2,ATP binding cassette,sub family B (MDR/TAP),member 3,ATP-binding cassette sub-family B member 3,D6S217E,Peptide supply factor 2,Peptide transporter involved in antigen processing 2,Peptide transporter PSF2,Peptide transporter TAP2,PSF 2,PSF-2,PSF2,Really interesting new gene 11 protein,RING 11,RING11,TAP 2,Tap2,TAP2,Transporter 2 ATP binding cassette sub family B,Transporter 2,ABC (ATP binding cassette,Transporter 2,ATP binding cassette,sub family B (MDR/TAP)

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

Molekulargewicht

Observed_MW: 76kDa

Calculated_MW: 72kDa/75kDa

Gen-ID 6891
UniProt Q03519
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2) antibody (ABIN6568799) Western blot analysis of extracts of various cell lines, using TAP2 antibody.
Image no. 2 for anti-Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2) antibody (ABIN6568799) Immunofluorescence analysis of U2OS cells using TAP2 antibody.