Synonyms: ABC transporter,MHC 2,ABC18,ABCB3,Antigen peptide transporter 2,APT2,ATP binding cassette,sub family B (MDR/TAP),member 3,ATP-binding cassette sub-family B member 3,D6S217E,Peptide supply factor 2,Peptide transporter involved in antigen processing 2,Peptide transporter PSF2,Peptide transporter TAP2,PSF 2,PSF-2,PSF2,Really interesting new gene 11 protein,RING 11,RING11,TAP 2,Tap2,TAP2,Transporter 2 ATP binding cassette sub family B,Transporter 2,ABC (ATP binding cassette,Transporter 2,ATP binding cassette,sub family B (MDR/TAP)
Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.