Synonyms: IA 2beta ,IA2beta ,IAR,IAR/receptor like protein tyrosine phosphatase,ICAAR,Islet cell autoantigen related protein,Islet cell autoantigen-related protein,Phogrin,Protein tyrosine phosphatase receptor pi ,Protein tyrosine phosphatase, receptor type, N polypeptide 2,PTPR2,Ptprn2,PTPRP ,R PTP N2,R-PTP-N2,Receptor-type tyrosine-protein phosphatase N2,Tyrosine phosphatase IA 2 beta
Background: This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants.