Synonyms: 5 HTT,5 HTTLPR,5 hydroxytryptamine (serotonin) transporter,5 hydroxytryptamine transporter,5HT transporter,5HTT,hSERT,HTT,Na+/Cl- dependent serotonin transporter,OCD1,SC6A4,Serotonin transporter 1,SERT,SERT1,Slc6a4,Sodium dependent serotonin transporter,Sodium-dependent serotonin transporter,Solute carrier family 6 (neurotransmitter transporter) member 4,solute carrier family 6 (neurotransmitter transporter,serotonin),member 4,Solute carrier family 6 member 4
Background: This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.