Synonyms: 8-dihydro-8-oxoguanine triphosphatase NUDT15,8-oxo-dGTPase NUDT15,A730068G11Rik,EC 3.1.6.-,FLJ10956,MGC104352,MTH2,MutT homolog 2,Nucleoside diphosphate-linked moiety X motif 15,NUD15,Nudix (nucleoside diphosphate linked moiety X)-type motif ,Nudix motif 15,NUDT15,OTTHUMP00000018389,Probable 7,Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15,RP11-90M2.1
Background: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.