EFCAB4B Antikörper
Kurzübersicht für EFCAB4B Antikörper (ABIN6568176)
Target
Alle EFCAB4B Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Aufreinigung
- Affinity purification
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Immunogen
- Recombinant fusion protein of human CRACR2A (NP_001138430.1).
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Isotyp
- IgG
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Applikationshinweise
- WB 1:500-1:2000 IHC 1:50-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
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Andere Bezeichnung
- CRACR2A
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Hintergrund
- Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
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Molekulargewicht
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Observed_MW: 45kDa
Calculated_MW: 45kDa/83kDa
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Gen-ID
- 84766
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UniProt
- Q9BSW2
Target
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