TNFRSF11A Antikörper (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator)

Produktnummer ABIN6567926

Produktdetails anti-TNFRSF11A Antikörper

Target:

TNFRSF11A

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF11A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human TNFRSF11A

Isotyp: IgG

Details zu TNFRSF11A

Target:

TNFRSF11A

Andere Bezeichnung: TNFRSF11A (TNFRSF11A Antibody Abstract)

Hintergrund:

Synonyms: CD 265,CD265,FEO,LOH18CR1,Loss of heterozygosity 18 chromosomal region 1,mRANK,ODFR,OFE,OPTB7,Osteoclast differentiation factor receptor,OSTS,Paget disease of bone 2,PDB 2,PDB2,RANK,Receptor activator of NF KB,Receptor activator of NF-KB,receptor activator of nuclear factor kappa B,TNF receptor superfamily member 11a,TNFRSF11A,TNR11,TRANCER,Tumor necrosis factor receptor superfamily member 11a NFKB activator,Tumor necrosis factor receptor superfamily member 11a activator of NFKB,Tumor necrosis factor receptor superfamily member 11A

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

Molekulargewicht:

Observed_MW: 90kDa

Calculated_MW: 28kDa/32kDa/36kDa/56kDa/64kDa/66kDa

Gen-ID: 8792

UniProt: Q9Y6Q6

Pathways: NF-kappaB Signalweg

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.