Synonyms: CHIT5 ,EGP ,Estrogen dependent oviduct protein,Estrogen-dependent oviduct protein,MUC9 ,mucin 9 ,Mucin-9,OGP ,OVGP 9,Ovgp1,OVGP1,Oviduct glycoprotein,Oviduct-specific glycoprotein,Oviductal glycoprotein,Oviductin
Background: This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions.