Elastase, Neutrophil Expressed (ELANE) Antikörper

Details zu Produkt Nr. ABIN6567736
Target
Reaktivität
Human, Maus
88
21
20
18
2
1
Wirt
Kaninchen
70
26
4
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
5
4
4
3
3
3
3
3
3
3
2
1
1
1
1
1
1
Applikation
Western Blotting (WB)
51
47
24
13
13
13
12
10
7
7
4
3
3
3
3
2
2
2
1
Optionen
Immunogen Recombinant Protein of human ELANE
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung ELANE (ELANE Antibody Abstract)
Hintergrund

Synonyms: Bone marrow serine protease,ELA2,ELANE,Elastase 2,Elastase 2 neutrophil ,Elastase neutrophil expressed,Elastase-2,ELNE,GE,Granulocyte derived elastase,HLE,HNE,Human leukocyte elastase,Leukocyte elastase,Medullasin,NE,Neutrophil elastase,PMN E,PMN elastase,Polymorphonuclear elastase,SCN1

Background: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.

Molekulargewicht

Observed_MW: 29kDa

Calculated_MW: 28kDa

Gen-ID 1991
UniProt P08246
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Elastase, Neutrophil Expressed (ELANE) antibody (ABIN6567736) Western blot analysis of extracts of various cell lines, using ELANE antibody.