Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Antikörper

Details zu Produkt Nr. ABIN6567396
Target
Reaktivität
Human, Maus, Ratte
106
26
26
2
2
1
1
1
1
1
1
Wirt
Kaninchen
75
27
7
Klonalität
Polyklonal
Konjugat
Unkonjugiert
12
7
7
7
7
7
2
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
102
71
62
27
21
16
13
4
4
4
1
Optionen
Immunogen Recombinant protein of human ALDH2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung ALDH2 (ALDH2 Antibody Abstract)
Hintergrund

Synonyms: Acetaldehyde dehydrogenase 2,Aldehyde dehydrogenase 2 family (mitochondrial),Aldehyde dehydrogenase 2 family,Aldehyde dehydrogenase mitochondrial,Aldehyde dehydrogenase,mitochondrial,ALDH 2,ALDH class 2,ALDH E2,ALDH-E2,Aldh2,ALDH2,ALDHI,ALDM,Liver mitochondrial ALDH,MGC1806,Mitochondrial aldehyde dehydrogenase 2,MS767,Nucleus encoded mitochondrial aldehyde dehydrogenase 2

Background: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50 % of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht

Observed_MW: 53kDa

Calculated_MW: 50kDa/56kDa

Gen-ID 217
UniProt P05091
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN6567396) Immunohistochemistry of paraffin-embedded human esophageal cancer using ALDH2 antibody.
Image no. 2 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN6567396) Immunohistochemistry of paraffin-embedded rat kidney using ALDH2 antibody.
Image no. 3 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN6567396) Western blot analysis of extracts of various cell lines, using ALDH2 antibody.
Image no. 4 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN6567396) Immunofluorescence analysis of A549 cells using ALDH2 antibody.