Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 317-517) Antikörper

Details zu Produkt Nr. ABIN1846467
Antigen
Epitop
AA 317-517
28
16
12
11
10
7
6
3
3
2
2
2
2
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
162
44
43
2
2
1
1
1
1
1
1
Wirt
Maus
115
45
7
Klonalität
Monoklonal
Konjugat
Unkonjugiert
12
7
7
7
7
7
2
2
2
2
2
2
Applikation
ELISA, Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC), Immunohistochemistry (IHC), Western Blotting (WB)
149
89
86
35
29
28
14
7
5
4
1
Optionen
Immunogen Purified recombinant fragment of human ALDH2 (AA: 317-517) expressed in E. coli.
Isotyp IgG1
Reinigung Purified antibody
Antigen
Andere Bezeichnung ALDH2 (ALDH2 Antibody Abstract)
Hintergrund This protein belongs to the aldehyde dehydrogenase family of proteins.Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism.Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations.Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme.A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme.The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer.This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Molekulargewicht 56.3 kDa
Gen-ID 217
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1.0 mg/mL
Buffer PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Bilder des Herstellers
Image no. 1 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 317-517) antibody (ABIN1846467) Western blot analysis using ALDH2 antibody against HepG2 (1), A549 (2) cell lysate, a...
Image no. 2 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 317-517) antibody (ABIN1846467) Flow cytometric analysis of HeLa cells using ALDH2 antibody (green) and negative cont...
Image no. 3 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 317-517) antibody (ABIN1846467) Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ALDH2 a...
Image no. 4 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 317-517) antibody (ABIN1846467) Immunofluorescence analysis of HepG2 cells using ALDH2 antibody (green). Blue: DRAQ5 ...
Image no. 5 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 317-517) antibody (ABIN1846467) Western blot analysis using ALDH2 antibody against HEK293 (1) and ALDH2 (AA: 317-517)...
Image no. 6 for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) (AA 317-517) antibody (ABIN1846467) Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using ALDH2...