PAX5 Antikörper

Produktnummer ABIN6567312

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PAX5 in WB. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für PAX5 Antikörper (ABIN6567312)

Target: PAX5 (Paired Box 5 (PAX5))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAX5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PAX5 Antikörper

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human PAX5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PAX5

Target: PAX5 (Paired Box 5 (PAX5))

Andere Bezeichnung: PAX5

Hintergrund:

Synonyms: B cell lineage specific activator,B cell lineage specific activator protein,B cell specific activator protein,B cell specific transcription factor,B-cell-specific transcription factor,BSAP,EBB-1,KLP,Paired box 5,Paired box gene 5 (B cell lineage specific activator protein),Paired box gene 5 (B cell lineage specific activator),Paired box gene 5,Paired box homeotic gene 5,Paired box protein Pax 5,Paired box protein Pax-5,Paired domain gene 5,PAX 5,PAX5,PAX5,Transcription factor PAX 5

Background: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht:

Observed_MW: 42kDa

Calculated_MW: 31kDa/32kDa/34kDa/35kDa/37kDa/38kDa/42kDa

Gen-ID: 5079

UniProt: Q02548