Synonyms: CDABP0042,CDC 47,CDC47,CDC47 homolog,Cdc47,S. cerevisiae,homolog of,DNA replication licensing factor MCM7,Homolog of S. cerevisiae Cdc47,MCM 2,MCM 7,MCM2,MCM2,formerly,Mcm7,MCM7 minichromosome maintenance deficient 7,MCM7,Minichromosome Maintainence 7,Minichromosome maintainence,S. cerevisiae,homolog of,Minichromosome maintenance complex component 7,Minichromosome maintenance deficient 7,Minichromosome maintenance protein 7,P1.1 MCM3,P1.1-MCM3,P1CDC47,P85MCM,PNAS 146,PNAS146,PPP1R104,Protein phosphatase 1,regulatory subunit 104
Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.