Minichromosome Maintenance Complex Component 7 (MCM7) Antikörper

Details zu Produkt Nr. ABIN6567128
Target
Reaktivität
Human, Maus
160
41
36
11
10
9
8
8
4
2
2
1
1
Wirt
Kaninchen
81
79
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
108
73
73
62
36
26
13
13
11
10
3
2
1
1
1
1
1
Optionen
Immunogen Recombinant protein of human MCM7
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung MCM7 (MCM7 Antibody Abstract)
Hintergrund

Synonyms: CDABP0042,CDC 47,CDC47,CDC47 homolog,Cdc47,S. cerevisiae,homolog of,DNA replication licensing factor MCM7,Homolog of S. cerevisiae Cdc47,MCM 2,MCM 7,MCM2,MCM2,formerly,Mcm7,MCM7 minichromosome maintenance deficient 7,MCM7,Minichromosome Maintainence 7,Minichromosome maintainence,S. cerevisiae,homolog of,Minichromosome maintenance complex component 7,Minichromosome maintenance deficient 7,Minichromosome maintenance protein 7,P1.1 MCM3,P1.1-MCM3,P1CDC47,P85MCM,PNAS 146,PNAS146,PPP1R104,Protein phosphatase 1,regulatory subunit 104

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Molekulargewicht

Observed_MW: 81kDa

Calculated_MW: 44kDa/60kDa/81kDa
Gen-ID 4176
UniProt P33993
Pathways DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Minichromosome Maintenance Complex Component 7 (MCM7) antibody (ABIN6567128) Western blot analysis of extracts of various cell lines, using MCM7 antibody.
Image no. 2 for anti-Minichromosome Maintenance Complex Component 7 (MCM7) antibody (ABIN6567128) Immunofluorescence analysis of HeLa cells using MCM7 antibody.