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DFFA Antikörper

Der Kaninchen Polyklonal Anti-DFFA-Antikörper wurde für WB und IF validiert. Er ist geeignet, DFFA in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN6566873

Kurzübersicht für DFFA Antikörper (ABIN6566873)

Target

Alle DFFA Antikörper anzeigen
DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Reaktivität

  • 79
  • 33
  • 22
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 80
  • 10
  • 1
Kaninchen

Klonalität

  • 81
  • 10
Polyklonal

Konjugat

  • 66
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DFFA Antikörper ist unkonjugiert

Applikation

  • 80
  • 28
  • 18
  • 17
  • 14
  • 14
  • 13
  • 12
  • 8
  • 6
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF)
  • Aufreinigung

    Affinity purification

    Immunogen

    Recombinant protein of human DFFA

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500 - 1:2000 IF 1:50 - 1:100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

    Andere Bezeichnung

    DFFA

    Hintergrund

    Synonyms: A330085O09Rik,Caspase activated deoxyribonuclease inhibitor short form,DFF 1,DFF 45,DFF alpha,DFF-45,DFF1,DFF35,DFF45,DFFA,Dffa DNA fragmentation factor,alpha subunit,DFFA,DNA fragmentation factor 45 kDa subunit,DNA Fragmentation Factor Alpha Subunit,DNA fragmentation factor subunit alpha,DNA fragmentation factor,45 kD,alpha subunit,DNA fragmentation factor,45  kDa,alpha polypeptide (DFFA),transcript variant 1,DNA fragmentation factor,45  kDa,alpha polypeptide,DNA fragmentation factor,alpha subunit,DNAation factor 45 kDa subunit,H13,ICAD,ICAD L,ICAD S,Inhibitor of CAD,Inhibitor of Caspase Activated DNase,MGC143066,OTTHUMP00000001903,OTTHUMP00000001904,RP23 121D17.3

    Background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

    Molekulargewicht

    Observed_MW: 35kDa, 45kDa

    Calculated_MW: 29kDa/36kDa

    Gen-ID

    1676

    UniProt

    O00273

    Pathways

    Apoptose, Caspase Kaskade in der Apoptose
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