Major Histocompatibility Complex Class I C (HLA-C) Antikörper

Details zu Produkt Nr. ABIN6566785
Target
Reaktivität
Human, Maus
57
5
3
1
1
1
1
Wirt
Kaninchen
53
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
7
6
3
3
2
1
1
1
1
1
1
Applikation
Western Blotting (WB)
38
32
9
5
5
4
4
2
1
Optionen
Immunogen Recombinant protein of human HLA-C
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung HLA-C (HLA-C Antibody Abstract)
Hintergrund

Synonyms: 1C07,Cw-7 alpha chain,D6S204,HLA class I histocompatibility antigen,HLA class I histocompatibility antigen, C alpha chain,HLA class I histocompatibility antigen, Cw-1 alpha chain,HLA-C,HLA-C histocompatibility type,HLA-Cw,HLA-JY3,HLAC,HLC-C,human leukocyte antigen-C alpha chain,major histocompatibility antigen HLA-C,major histocompatibility complex, class I, C ,MHC class I antigen,MHC class I antigen Cw 1,MHC class I antigen Cw*7,MHC class I antigen heavy chain HLA-C,PSORS1

Background: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described

Molekulargewicht

Observed_MW: 41kDa

Calculated_MW: 41kDa

Gen-ID 3107
UniProt P10321
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Major Histocompatibility Complex Class I C (HLA-C) antibody (ABIN6566785) Western blot analysis of extracts of various cell lines, using HLA-C antibody.