HLA-C Antikörper

Produktnummer ABIN6566785

Dieses Anti-HLA-C-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HLA-C in WB. Geeignet für Human und Maus.

Kurzübersicht für HLA-C Antikörper (ABIN6566785)

Target: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HLA-C Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human HLA-C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HLA-C

Target: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Andere Bezeichnung: HLA-C

Hintergrund:

Synonyms: 1C07,Cw-7 alpha chain,D6S204,HLA class I histocompatibility antigen,HLA class I histocompatibility antigen, C alpha chain,HLA class I histocompatibility antigen, Cw-1 alpha chain,HLA-C,HLA-C histocompatibility type,HLA-Cw,HLA-JY3,HLAC,HLC-C,human leukocyte antigen-C alpha chain,major histocompatibility antigen HLA-C,major histocompatibility complex, class I, C ,MHC class I antigen,MHC class I antigen Cw 1,MHC class I antigen Cw*7,MHC class I antigen heavy chain HLA-C,PSORS1

Background: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described

Molekulargewicht:

Observed_MW: 41kDa

Calculated_MW: 41kDa

Gen-ID: 3107

UniProt: P10321

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response