GEN1 Antikörper

Produktnummer ABIN6566734

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GEN1 in WB. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für GEN1 Antikörper (ABIN6566734)

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GEN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GEN1 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human GEN1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GEN1

Target: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Andere Bezeichnung: GEN1

Hintergrund:

Synonyms: DKFZp781F0986,Flap endonuclease GEN homolog 1,FLJ40869,GEN 1,Gen,Gen homolog 1 endonuclease (Drosophila),Gen homolog 1 endonuclease,GEN,GEN1

Background: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.

Molekulargewicht:

Observed_MW: 103kDa

Calculated_MW: 102kDa

Gen-ID: 348654

UniProt: Q17RS7

Pathways: DNA Reparatur