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RPA1 Antikörper

RPA1 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6566683
  • Target Alle RPA1 Antikörper anzeigen
    RPA1 (Replication Protein A1, 70kDa (RPA1))
    Reaktivität
    • 81
    • 25
    • 16
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 67
    • 13
    • 1
    • 1
    Kaninchen
    Klonalität
    • 67
    • 15
    Polyklonal
    Konjugat
    • 46
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RPA1 Antikörper ist unkonjugiert
    Applikation
    • 69
    • 32
    • 20
    • 15
    • 14
    • 13
    • 13
    • 12
    • 9
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human RPA1 (NP_002936.1).
    Isotyp
    IgG
    Top Product
    Discover our top product RPA1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000 IHC 1:50-1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    RPA1 (Replication Protein A1, 70kDa (RPA1))
    Andere Bezeichnung
    RPA1 (RPA1 Produkte)
    Synonyme
    HSSB antikoerper, MST075 antikoerper, REPA1 antikoerper, RF-A antikoerper, RP-A antikoerper, RPA70 antikoerper, Cb1-727 antikoerper, wu:fi14b08 antikoerper, zgc:55337 antikoerper, zgc:77092 antikoerper, RPA1 antikoerper, hssb antikoerper, mst075 antikoerper, repa1 antikoerper, rf-a antikoerper, rp-a antikoerper, rpa antikoerper, rpa70 antikoerper, LOC100230990 antikoerper, 5031405K23Rik antikoerper, 70kDa antikoerper, AA589576 antikoerper, AW557552 antikoerper, Rpa antikoerper, CG9633 antikoerper, D-RPA70 antikoerper, D-SSB antikoerper, DRP-A antikoerper, DmRPA antikoerper, Dmel\\CG9633 antikoerper, RPA antikoerper, RPA 70 antikoerper, RPA 70 kDa antikoerper, RpA70 antikoerper, Rpa-70 antikoerper, Ssb-70 antikoerper, dRP-A antikoerper, dmrpa1 antikoerper, i164 antikoerper, replication protein A1 antikoerper, replication protein A1, 70kDa antikoerper, replication protein A1 L homeolog antikoerper, Replication Protein A 70 antikoerper, RPA1 antikoerper, Rpa1 antikoerper, rpa1 antikoerper, rpa1.L antikoerper, RpA-70 antikoerper
    Hintergrund
    This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways.
    Molekulargewicht

    Observed_MW: 70kDa

    Calculated_MW: 68kDa

    Gen-ID
    6117
    UniProt
    P27694
    Pathways
    Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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