NOTCH2 Antikörper (Notch 2)

Details for Product anti-NOTCH2 Antibody No. ABIN6566613
Target
Reaktivität
Human, Maus
88
43
38
7
7
4
3
2
2
1
1
1
1
1
Wirt
Kaninchen
73
8
6
5
1
1
Klonalität
Polyklonal
Konjugat
Dieser NOTCH2 Antikörper ist unkonjugiert
6
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
53
47
31
17
14
10
8
5
3
3
1
1
Optionen
Immunogen Recombinant protein of human NOTCH2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung NOTCH2 (NOTCH2 Antibody Abstract)
Hintergrund

Synonyms: AGS2,hN2,Motch B,N2,N2ECD,N2ICD,neurogenic locus notch homolog protein 2,NOTC2,Notch 2,Notch 2 intracellular domain,Notch Drosophila homolog 2,Notch homolog 2,Notch homolog 2 Drosophila,Notch2

Background: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht

Observed_MW: 120kDa

Calculated_MW: 265kDa

Gen-ID 4853
UniProt Q04721
Pathways Notch Signalweg, Stem Cell Maintenance
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:100 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Notch 2 (NOTCH2) antibody (ABIN6566613) Western blot analysis of extracts of various cell lines, using NOTCH2 antibody.
Image no. 2 for anti-Notch 2 (NOTCH2) antibody (ABIN6566613) Immunohistochemistry of paraffin-embedded human stomach using NOTCH2 antibody.
Image no. 3 for anti-Notch 2 (NOTCH2) antibody (ABIN6566613) Immunohistochemistry of paraffin-embedded mouse brain using NOTCH2 antibody.