beta Amyloid Antikörper

Produktnummer ABIN6566498

Der Kaninchen Polyklonal Anti-beta Amyloid-Antikörper wurde für WB und IHC validiert. Er ist geeignet, beta Amyloid in Proben von Human zu detektieren.

Kurzübersicht für beta Amyloid Antikörper (ABIN6566498)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-beta Amyloid Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human APP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: beta Amyloid

Hintergrund:

Synonyms: A4 amyloid protein,A4,AAA,ABETA,ABPP,AD1,AICD-50,AICD-57,AICD-59,AID(50),AID(57),AID(59),Alzheimer disease amyloid protein,Amyloid beta (A4) precursor protein,Amyloid beta A4 protein,Amyloid beta protein,Amyloid intracellular domain 50,Amyloid intracellular domain 57,Amyloid intracellular domain 59,Amyloid precursor protein,APP,APPI,Beta amyloid peptide,Beta-amyloid precursor protein,Beta-APP40,Beta-APP42,C31,Cerebral vascular amyloid peptide,CTFgamma,CVAP,Gamma-CTF(50),Gamma-CTF(57),Gamma-CTF(59),peptidase nexin II,PN 2,PN II,PN-II,PN2,PreA4,Protease nexin II,Protease nexin-II,S-APP-alpha,S-APP-beta

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Molekulargewicht:

Observed_MW: 110kDa

Calculated_MW: 34kDa/72-86kDa

Gen-ID: 351

UniProt: P05067

Pathways: Inflammasome